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  • About Us
    • Our Mission
    • Management
    • Board of Directors
    • Advisory Board
    • Our Team
  • Our Science
    • Ionic Liquid Platform
    • Clinical Focus
    • Clinical Results
  • Career
  • More
    • Clinical Trials
    • Press Releases
    • In the News
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Our science

Ionic liquid technology for skin penetration

CAGE Bio is a biotech company using ionic liquid technology for skin penetration, keeping drug concentration in blood plasma minimal and helping to improve safety. Our topical programs for moderate to severe skin diseases span atopic dermatitis, vitiligo and alopecia areata, with DNA aptamer and siRNA candidates.

3D ball-and-stick model of an ionic liquid molecule used in CAGE Bio topical drug delivery

What is an Ionic Liquid?

An ionic liquid (IL) is a liquid salt in which the ions are poorly coordinated by association only with ionic bonds and no covalent bonds. As a result, these solvents remain liquid at or below room temperature and have excellent solvation properties with very low vapor pressure.

How does it work?

Ionic Liquid Platform uses structural heterogeneity of cations & anions to enhance membrane permeation.

Capsule releasing drug molecules: delivery of small molecules, peptides, proteins and nucleic acids

Delivers wide range of drug APIs including small molecules, peptides, proteins and nucleic acids across the stratum corneum following topical administration, with minimal impact on barrier function.

Negative and positive ions, illustrating the tunable cation and anion pairs of ionic liquids

Enables choice of cations and anions to engineer diverse ILs with 

tailor‐made properties for multiple therapeutic areas. 

Crossed-out pathogen icon representing the anti-microbial properties of ionic liquids

Extensive anti-microbial properties. 

Illustration of skin layers with ionic liquid molecules penetrating the epidermis and dermis

BEST-IN-CLASS platform for immuno-dermatological diseases

CAGE Bio has accumulated a vast amount of in vitro and in vivo evidence supporting the role of ionic liquids in improving tissue-specific delivery of therapeutic entities into the skin.

Learn more
Comparing Ionic Liquid vs. common Skin Penetration Enhancers

Learn the science behind ionic liquids


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